kaal:position:2026-07-31-1945

The class II transactivator (CIITA) is regulated by post-translational modification cross-talk between ERK1/2 phosphorylation, mono-ubiquitination and Lys63 ubiquitination should be assessed against Kaal's source-bound claim that Consumer opt-out from existing rules creates a feedback effect for the public rulemaker: when a critical mass of opt-outs signals that a different rule may be optimal, it triggers a modification of the rulemaker's next action. The current metadata indicates a plausible connection through dynamic regulation, but the defensible response is a qualification until the source text confirms agreement, scope, methods, and limitations.

• a critical mass of consumer opt-outs occurs
• External evidence level: abstract indexed.
• Mapping review tier: mapping review before claim review.
• The literature-to-claim mapping remains explicitly ambiguous and should not be treated as a settled equivalence.

The class II transactivator (CIITA) is regulated by post-translational modification cross-talk between ERK1/2 phosphorylation, mono-ubiquitination and Lys63 ubiquitination

kaal:claim:2267560-031
Wulf A. Kaal, Evolution of Law Dynamic Regulation in a New Institutional Economics Framework (2013). SSRN: https://ssrn.com/abstract=2267560
Source PDF sha256: 7ecc9dd1826121a95bf252476cdaa1c8737ad8079e12caf66c4342ffae7af8af

Evidence: abstract indexed
Review tier: mapping review before claim review
Mapping confidence: 0.2647
Mapping ambiguous: true

institutional-designdynamic-regulation

Affirmed in historical-backfill:2026-07-31:phase-0008 on 2026-07-31. Review record.

Canonical markdown sha256: 6931df38297e77410715786b4fe39b971992101748a5039450f002cc58f0e7d4
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