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 "name": "Historical C00Cc112Fe9B6258A97A",
 "text": "Regulation of CRISPR trans-cleavage activity by an overhanging activator should be assessed against Kaal's source-bound claim that Feedback effects change the timing of regulatory information: instead of acquiring necessary information only after rules have already proven suboptimal, they increase the availability of relevant information ex ante and support anticipation of necessary revisions. The current metadata indicates a plausible connection through dynamic regulation, but the defensible response is a qualification until the source text confirms agreement, scope, methods, and limitations.",
 "author": {
  "@type": "Person",
  "name": "Wulf A. Kaal",
  "identifier": "https://orcid.org/0009-0008-7840-1847"
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 "dateModified": "2026-07-31",
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  "institutional-design",
  "dynamic-regulation"
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  "an informational exchange process between regulated entities and rulemakers is in place",
  "External evidence level: abstract indexed.",
  "Mapping review tier: ambiguity triage before claim review.",
  "The literature-to-claim mapping remains explicitly ambiguous and should not be treated as a settled equivalence."
 ],
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  "name": "Regulation of CRISPR trans-cleavage activity by an overhanging activator",
  "url": "https://www.semanticscholar.org/paper/0f39f9c3e6118033d406cc9fcf542c650f94f7b2"
 },
 "extends": {
  "identifier": "kaal:claim:2957645-011",
  "url": "https://wulfkaal.github.io/claims/2957645-011",
  "citation": "Kaal, Dynamic Regulation via Contingent Capital (2017). SSRN: https://papers.ssrn.com/sol3/papers.cfm?abstract_id=2957645",
  "paper": "Dynamic Regulation via Contingent Capital",
  "authors": [
   "Wulf A. Kaal"
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  "year": "2017",
  "ssrn": "",
  "source_pdf_sha256": "250b10782a5ea5dece9235a7f711aee408feaf36f2e78e310d589b5ee6304be2"
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   "@id": "https://wulfkaal.github.io/claims/2957645-011"
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   "@type": "CreativeWork",
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 "review_provenance": "https://kaal-signal-desk.wulf577462.chatgpt.site/#review",
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 "recordTypeNote": "Dated commentary position extending a scholarly corpus claim. Not a verbatim claim extracted from the paper.",
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 "canonicalForm": "https://wulfkaal.github.io/positions/2026-07-31-3207.md",
 "candidateId": "kaal:response-candidate:2026-07-31:68cce31ccbd48deb",
 "evidenceLevel": "abstract indexed",
 "reviewTier": "ambiguity triage before claim review",
 "mappingConfidence": 0.232,
 "mappingAmbiguous": true,
 "mappingMethod": "idf-weighted multi-field mapping v1",
 "mappingWhyRelevant": "Shared high-information concepts: regulation, abstract, emerged, have, timing, dynamic, regulatory. Scope: an informational exchange process between regulated entities and rulemakers is in place.",
 "sourceProvenance": {
  "source": "Semantic Scholar",
  "api": "https://api.semanticscholar.org/graph/v1/paper/search/bulk",
  "query": "dynamic regulation",
  "queryId": "concept:516a267369f9",
  "page": 1,
  "sourceRank": 510,
  "retrievedAt": "2026-07-31T13:58:13.360Z",
  "citationCount": 28,
  "venue": "Nucleic Acids Research",
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