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 "@context": "https://schema.org",
 "@type": "Claim",
 "@id": "https://wulfkaal.github.io/positions/2026-07-31-6790",
 "identifier": "kaal:position:2026-07-31-6790",
 "additionalType": "https://wulfkaal.github.io/positions/schema.json#AffirmedPositionClaim",
 "name": "Streaming Signal Transduction From N Cadherin Increases Bcl 2 B19Db3Bbaa",
 "text": "Signal Transduction from N-cadherin Increases Bcl-2 presents the following source proposition: Associated with the metastatic progression of epithelial tumors is the dynamic regulation of cadherins. This proposition is pertinent to Kaal's source-bound claim that The collective action problem of rulemaking, the problems of trial-and-error rulemaking, and the problems of regulatory cycles derive largely from the nature of stable and presumptively optimal rules themselves, not from unrelated institutional defects. The proposed response is an extension: the relationship should remain limited to the retrieved source proposition and the mapped Kaal claim unless fuller source review supports a broader conclusion.",
 "author": {
  "@type": "Person",
  "name": "Wulf A. Kaal",
  "identifier": "https://orcid.org/0009-0008-7840-1847"
 },
 "datePublished": "2026-07-31",
 "dateModified": "2026-07-31",
 "creativeWorkStatus": "Affirmed",
 "responseType": "extension",
 "keywords": [
  "institutional-design",
  "dynamic-regulation",
  "historical-response",
  "scholarly-literature",
  "semantic-scholar"
 ],
 "scope_conditions": [
  "The response is limited to the retrieved source proposition and mapped Kaal claim unless fuller source review supports a broader conclusion.",
  "External evidence level: abstract indexed.",
  "Mapping review tier: moderate-confidence claim review.",
  "Primary mapping confidence: 0.3605.",
  "The source-to-claim mapping remains explicitly ambiguous and is published with that limitation."
 ],
 "currentDebate": {
  "name": "Signal Transduction from N-cadherin Increases Bcl-2",
  "url": "https://www.semanticscholar.org/paper/653b7843bbd9dbe173f29e04561f70ac5c274358"
 },
 "extends": {
  "identifier": "kaal:claim:2808132-028",
  "url": "https://wulfkaal.github.io/claims/2808132-028",
  "citation": "Wulf A. Kaal, Erik P.M. Vermeulen, How to Regulate Disruptive Innovation - From Facts to Data (2016). SSRN: https://ssrn.com/abstract=2808132",
  "paper": "Wulf A. Kaal, Erik P.M. Vermeulen, How to Regulate Disruptive Innovation - From Facts to Data",
  "authors": [
   "Wulf A. Kaal"
  ],
  "year": "2016",
  "ssrn": "https://ssrn.com/abstract=2808132",
  "source_pdf_sha256": "3515f2317ed9c1d33ae55d70467cdf1f6c4e350065ea6a887d5d7619599ad7d2"
 },
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  {
   "@id": "https://wulfkaal.github.io/claims/2808132-028"
  },
  {
   "@type": "CreativeWork",
   "name": "Signal Transduction from N-cadherin Increases Bcl-2",
   "url": "https://www.semanticscholar.org/paper/653b7843bbd9dbe173f29e04561f70ac5c274358"
  }
 ],
 "batch_id": "kaal-review:2026-07-31:streaming-etl-0006",
 "review_provenance": "https://kaal-signal-desk.wulf577462.chatgpt.site/#review",
 "publicationStatus": "public",
 "recordTypeNote": "Dated commentary position extending a scholarly corpus claim. Not a verbatim claim extracted from the paper.",
 "isPartOf": {
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 "candidateId": "kaal:response-draft:2026-07-31:ca43382ba9daa563136c",
 "evidenceLevel": "abstract indexed",
 "reviewTier": "moderate-confidence claim review",
 "mappingConfidence": 0.3605,
 "mappingAmbiguous": true,
 "mappingMethod": "idf-weighted multi-field mapping v1",
 "mappingWhyRelevant": "Shared high-information concepts: increases, associated, dynamic, regulation. Scope: regulatory regimes whose outcomes are stable rather than adaptive.",
 "sourceProvenance": {
  "source": "semantic-scholar",
  "sourceRecordId": "653b7843bbd9dbe173f29e04561f70ac5c274358",
  "queryId": "concept:516a267369f9",
  "queryText": "dynamic regulation",
  "canonicalUrl": "https://www.semanticscholar.org/paper/653b7843bbd9dbe173f29e04561f70ac5c274358",
  "doi": "10.1074/jbc.m200300200",
  "externalIds": {
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   "DOI": "10.1074/jbc.M200300200",
   "CorpusId": 26102739,
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  "retrievedAt": "2026-07-31T13:58:16.518Z",
  "providerPage": 4,
  "rawObservationSha256": "5547e3755353e3c8f7e38d9db6f1c64c6f77de1cea2c70a80a7a154d4ee2257a",
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  "workId": "work:doi:10.1074/jbc.m200300200",
  "workAuthors": [
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   "R. Vaillancourt",
   "R. Heimark"
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  "workPublishedAt": "2002-09-06",
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    "rank": 1,
    "confidence": 0.3605,
    "method": "idf-weighted multi-field mapping v1",
    "whyRelevant": "Shared high-information concepts: increases, associated, dynamic, regulation. Scope: regulatory regimes whose outcomes are stable rather than adaptive.",
    "ambiguous": true
   },
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    "whyRelevant": "Shared high-information concepts: signal, dynamic, regulation. Scope: review source claim scope.",
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    "whyRelevant": "Shared high-information concepts: signal, dynamic, regulation. Scope: review source claim scope.",
    "ambiguous": true
   },
   {
    "claimId": "kaal:claim:2834531-032",
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    "rank": 4,
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    "method": "idf-weighted multi-field mapping v1",
    "whyRelevant": "Shared high-information concepts: signal, dynamic, regulation. Scope: where venture and investment data on the technology are available.",
    "ambiguous": true
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   {
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    "method": "idf-weighted multi-field mapping v1",
    "whyRelevant": "Shared high-information concepts: increases, dynamic, regulation. Scope: institution specific information is actually generated and available.",
    "ambiguous": true
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 "userAffirmation": "I affirm batch kaal-review:2026-07-31:streaming-etl-0006, SHA-256 d724cb4e85d4ecdf4e8488b6b1c8ed999688fe58732ad5a50c5c197c25427f43, as written and authorize publication of all 250 response claims on my canonical property, preserving their evidence levels, ambiguity labels, provenance, and the unchanged 5,033 scholarly claims.",
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}