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 "name": "Streaming Abstract 464 Dynamic Regulation Of The Epidermal Growth Factor Receptor  28D8358Dc2",
 "text": "Abstract 464: Dynamic Regulation of the Epidermal Growth Factor Receptor Protein Interactome via β1-adrenergic Receptor-mediated Transactivation in Cardiomyocytes presents the following source proposition: Our ongoing goal is to develop new signaling modalities as refined HF therapeutics. This proposition is pertinent to Kaal's source-bound claim that Contingent capital qualifies as a dynamic regulatory mechanism because capital injection is available only if and when needed and because the conversion of contingent capital securities into near worthless equity signals impending regulatory issues to regulators, which creates feedback effects. The proposed response is an extension: the relationship should remain limited to the retrieved source proposition and the mapped Kaal claim unless fuller source review supports a broader conclusion.",
 "author": {
  "@type": "Person",
  "name": "Wulf A. Kaal",
  "identifier": "https://orcid.org/0009-0008-7840-1847"
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 "datePublished": "2026-07-31",
 "dateModified": "2026-07-31",
 "creativeWorkStatus": "Affirmed",
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  "dynamic-regulation",
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  "semantic-scholar"
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  "The response is limited to the retrieved source proposition and mapped Kaal claim unless fuller source review supports a broader conclusion.",
  "External evidence level: abstract indexed.",
  "Mapping review tier: moderate-confidence claim review.",
  "Primary mapping confidence: 0.3526.",
  "The source-to-claim mapping remains explicitly ambiguous and is published with that limitation."
 ],
 "currentDebate": {
  "name": "Abstract 464: Dynamic Regulation of the Epidermal Growth Factor Receptor Protein Interactome via β1-adrenergic Receptor-mediated Transactivation in Cardiomyocytes",
  "url": "https://www.semanticscholar.org/paper/93d027eb5adf94d2bdc69ba85d50afb28260bcdd"
 },
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  "identifier": "kaal:claim:2957645-025",
  "url": "https://wulfkaal.github.io/claims/2957645-025",
  "citation": "Kaal, Dynamic Regulation via Contingent Capital (2017). SSRN: https://papers.ssrn.com/sol3/papers.cfm?abstract_id=2957645",
  "paper": "Kaal, Dynamic Regulation via Contingent Capital",
  "authors": [
   "Wulf A. Kaal"
  ],
  "year": "2017",
  "ssrn": null,
  "source_pdf_sha256": "250b10782a5ea5dece9235a7f711aee408feaf36f2e78e310d589b5ee6304be2"
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   "@id": "https://wulfkaal.github.io/claims/2957645-025"
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   "name": "Abstract 464: Dynamic Regulation of the Epidermal Growth Factor Receptor Protein Interactome via β1-adrenergic Receptor-mediated Transactivation in Cardiomyocytes",
   "url": "https://www.semanticscholar.org/paper/93d027eb5adf94d2bdc69ba85d50afb28260bcdd"
  }
 ],
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 "review_provenance": "https://kaal-signal-desk.wulf577462.chatgpt.site/#review",
 "publicationStatus": "public",
 "recordTypeNote": "Dated commentary position extending a scholarly corpus claim. Not a verbatim claim extracted from the paper.",
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 "reviewTier": "moderate-confidence claim review",
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 "mappingAmbiguous": true,
 "mappingMethod": "idf-weighted multi-field mapping v1",
 "mappingWhyRelevant": "Shared high-information concepts: abstract, dynamic, regulation, via, signaling. Scope: contingent capital securities are outstanding and their conversion is observable by regulators.",
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  "queryId": "concept:516a267369f9",
  "queryText": "dynamic regulation",
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  "doi": "10.1161/res.127.suppl_1.464",
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  "workAuthors": [
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    "method": "idf-weighted multi-field mapping v1",
    "whyRelevant": "Shared high-information concepts: abstract, dynamic, regulation, via, signaling. Scope: contingent capital securities are outstanding and their conversion is observable by regulators.",
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    "whyRelevant": "Shared high-information concepts: abstract, dynamic, regulation, via, new. Scope: regulation of innovative products and markets; existing regulatory framework built on stable rules.",
    "ambiguous": true
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